![]() ![]() ![]() ![]() Age, BMI, and biological factors, such as the elevated serum MMP-3 concentration, have also been mentioned in clinical description. The clinical features include 3 years of preceding hip pain which deteriorates in the recent 6 months, while hip mobility is relatively spared. In order to facilitate a timely diagnosis without necessitating 12-month serial follow-ups, Zazgyva et al proposed clinico-radiological descriptive criteria for RPOA, emphasizing the presence of subchondral cysts (geodes) in the acetabulum and femoral head with a relative absence of osteophytes as the hallmark features of RPOA. It is controversial whether bone destruction occurs as the late sequelae of cartilage destruction, or it is another disease entity distinctly different from RPOA without bone destruction. In some patients, however, rapid chondrolysis may develop, with subsequent destruction of the femoral head and acetabulum within 12 months following initial presentation. The diagnosis established based on these diagnostic criteria entails observation for a long period of time. Meanwhile, other causes of rapidly destructive conditions, such as avascular necrosis (AVN), Charcot neuroarthropathy and infection are excluded. Lequesne et al proposed the first and most popularly adopted diagnostic criteria, including progressive chondrolysis exceeding 2 mm per year or the loss of more than 50% joint space within 1 year. Though the disease entity has been described by multiple studies, the quantitative diagnostic criteria have not yet been reported. The reported incidence of RPOA is 16, and 10% of total hip arthroplasties fulfilled the diagnosis of RPOA. Rapidly progressive osteoarthritis (RPOA) of the hip, also known as rapidly destructive osteoarthritis of hip, is a rare pathological condition manifesting as rapid chondrolysis (Type 1 RPOA) followed by hip joint destruction (Type 2 RPOA). ![]()
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